Here Are The 4 Skincare Ingredients Proven To Work
Here Are The 4 Skincare Ingredients Actually Proven To Work
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When it comes to skincare, the sheer number of products and ingredients available on the market right now can be overwhelming. While some skincare trends come and go, there are a few tried-and-true ingredients backed by science that deliver real, long-term results. According to a recent article posted by New Scientist on Dec. 23, 2024, these powerhouse ingredients include retinoids, vitamin C, niacinamide, and alpha hydroxy acids (AHAs). While other ingredients like hyaluronic acid are wonderful for temporarily plumping and hydrating the skin, these four offer more substantial, lasting benefits that can transform your skin’s health and glow over time.

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1. Retinoids: The Anti-Aging Superstar
Retinoids, derived from Vitamin A, have been hailed as the gold standard in anti-aging skincare for decades. They work by promoting cell turnover, meaning they encourage the skin to shed dead cells and reveal fresher, healthier skin underneath. This process helps to reduce the appearance of fine lines and wrinkles, improve skin texture, and even out skin tone.
But retinoids aren’t just for aging skin. They are also highly effective in treating acne, as they help to prevent clogged pores by encouraging the shedding of skin cells. There are several types of retinoids, including over-the-counter options like retinol and stronger, prescription-only varieties like tretinoin.
According to Medical News Today, this powerful skincare ingredient can be used to fight severe skin conditions like psoriasis, an autoimmune disorder that causes skin cells to rapidly multiply resulting in painful dry red patches or scales on the skin. It can also stimulate collagen production, reduce inflammation, and help the skin maintain a healthy glow. It’s important to note that retinoids can cause dryness and irritation, especially when you first introduce them into your routine, so it’s essential to start slow.
2. Vitamin C: The Brightening Powerhouse

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Vitamin C is an antioxidant that offers a multitude of benefits for the skin, but it’s most famous for its ability to brighten dull or uneven skin. It works by neutralizing free radicals, which are unstable molecules that can damage skin cells and accelerate the aging process. Additionally, vitamin C plays a crucial role in collagen synthesis, which helps keep the skin firm and youthful.
As a brightening agent, vitamin C helps to fade dark spots and eliminate hyperpigmentation, and discoloration caused by sun exposure or acne scars, Healthline notes. With regular use, your complexion can look more even and radiant. It can also reduce the appearance of sagging and protect against environmental damage from the sun.
To get the most out of vitamin C, apply it in the morning as the first step in your skincare routine, followed by sunscreen. Try finding a good cleanser with vitamin C that will help give your skin a jumpstart in the morning. Emma Craythorne, a dermatologist and founder of the bespoke prescription skincare company Klira, suggests cleansing twice a day to remove unwanted build-up, sweat, and pollutants from the skin in the morning and at night.
“The breakdown of those chemicals can cause a stress response in the skin, so it is important to get those things off,” Craythorne told New Scientist. “It is also important because our skin cells [are constantly replaced], otherwise you end up with bits of dead skin stuck to you like a crusty scale.”
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3. Niacinamide: The Soothing Multitasker
Niacinamide, also known as Vitamin B3, has gained immense popularity in recent years due to its impressive versatility. It’s one of the few ingredients that work for all skin types, from dry and sensitive to oily and acne-prone. Niacinamide is particularly renowned for its ability to improve the skin’s barrier function, which helps lock in moisture and protect the skin from environmental stressors.
Niacinamide, also known as Vitamin B3, is a skincare powerhouse with a broad range of benefits. It can reduce redness, soothe inflammation, and help treat acne, making it an excellent option for those with sensitive or blemish-prone skin. Additionally, niacinamide is known to brighten the complexion, minimize the appearance of fine lines and wrinkles, and offer some protection against UV damage.
A 2021 review further emphasized niacinamide’s versatility, suggesting that it could be beneficial for a variety of skin concerns, including signs of aging, psoriasis flare-ups, hyperpigmentation, and even reducing the risk of non-melanoma skin cancers. Its wide-reaching effects make niacinamide a must-have ingredient for anyone looking to enhance skin health and appearance.
Pro Tip: After using a cleanser and a vitamin C serum, follow up with a niacinamide serum, which will help to reduce inflammation, reduce redness, and improve the skin’s texture.
4. Alpha Hydroxy Acids (AHAs): Exfoliation Made Easy
Alpha hydroxy acids, or AHAs, are a group of water-soluble acids derived from natural foods. The most common AHA is glycolic acid, but others like lactic acid and citric acid are also popular. AHAs work by gently exfoliating the surface of the skin, removing dead skin cells to reveal a smoother, brighter complexion.
In addition to their exfoliating properties, AHAs also promote collagen production and help to improve skin texture over time. They can fade dark spots, fine lines, and even improve skin tone by reducing the buildup of dead skin that can make your complexion look dull, according to the Food and Drug Administration (FDA). Since AHAs exfoliate the skin, they can make your skin more sensitive to the sun.
Be sure to apply them in the evening and follow up with a good moisturizer to help the skin retain hydration.

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Why do these four ingredients work in the long term?
While ingredients like hyaluronic acid are great for providing instant hydration and plumping the skin, the ingredients we’ve covered—retinoids, vitamin C, niacinamide, and AHAs—offer more than just temporary improvements. They work at a deeper, cellular level to improve the skin’s health and appearance over time, helping to address signs of aging, pigmentation, and texture issues.
If you’re looking for long-term results rather than quick fixes, incorporating these four proven ingredients into your skincare routine can make a significant difference.
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